| Autor: |
Edit Hathy, Eszter Szabó, Katalin Vincze, Irén Haltrich, Eszter Kiss, Nóra Varga, Zsuzsa Erdei, György Várady, László Homolya, Ágota Apáti, János M. Réthelyi |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Stem Cell Research, Vol 51, Iss , Pp 102140- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1873-5061 |
| DOI: |
10.1016/j.scr.2020.102140 |
| Popis: |
Here we describe the generation of induced pluripotent stem cell lines from each member - male proband, mother, father - of a schizophrenia case-parent trio that participated in an exome sequencing study, and 3 de novo mutations were identified in the proband. Peripheral blood mononuclear cells were obtained from all three individuals and reprogrammed using Sendai virus particles carrying the Yamanaka transgenes. These 3 iPSC lines (iPSC-SZ-HU-MO 1, iPSC-SZ-HU-FA 1, and iPSC-SZ-HU-PROB 1) represent a resource for examining the functional significance of the identified de novo mutations in the molecular pathophysiology of schizophrenia. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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