Preliminary Attempt to Predict Risk of Invasive Pulmonary Aspergillosis in Patients with Influenza: Decision Trees May Help?

Autor: Valeria Bellelli, Guido Siccardi, Livia Conte, Luigi Celani, Elena Congeduti, Cristian Borrazzo, Letizia Santinelli, Giuseppe Pietro Innocenti, Claudia Pinacchio, Giancarlo Ceccarelli, Mario Venditti, Gabriella d’Ettorre
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Antibiotics, Vol 9, Iss 10, p 644 (2020)
Druh dokumentu: article
ISSN: 2079-6382
DOI: 10.3390/antibiotics9100644
Popis: Invasive pulmonary aspergillosis (IPA) is typically considered a disease of immunocompromised patients, but, recently, many cases have been reported in patients without typical risk factors. The aim of our study is to develop a risk predictive model for IPA through machine learning techniques (decision trees) in patients with influenza. We conducted a retrospective observational study analyzing data regarding patients diagnosed with influenza hospitalized at the University Hospital “Umberto I” of Rome during the 2018-2019 season. We collected five IPA cases out of 77 influenza patients. Although the small sample size is a limit, the most vulnerable patients among the influenza-infected population seem to be those with evidence of lymphocytopenia and those that received corticosteroid therapy.
Databáze: Directory of Open Access Journals