Autor: |
G. Brent Dawe, Hong Yu, Shenyan Gu, Alissa N. Blackler, Jose A. Matta, Edward R. Siuda, Elizabeth B. Rex, David S. Bredt |
Jazyk: |
angličtina |
Rok vydání: |
2019 |
Předmět: |
|
Zdroj: |
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019) |
Druh dokumentu: |
article |
ISSN: |
2041-1723 |
DOI: |
10.1038/s41467-019-10723-x |
Popis: |
The α7 nicotinic acetylcholine receptor (nAChR) plays a major role in shaping the activity of neuronal circuits and contributes to the pathophysiology of several neurological disorders. Following cDNA library screening, the authors identify anti-apoptotic, Bcl-2 family proteins as enhancers of α7 nAChR assembly, acting through an intracellular BH3-like domain during receptor biogenesis in the endoplasmic reticulum. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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