Novel inflammatory and insulin resistance indices provide a clue in cerebral amyloid angiopathy

Autor:	Hang-hang Zhu, Yun-chao Wang, Liu-chang He, Hai-yang Luo, Ce Zong, Ying-hao Yang, Jing-Hao Wu, Bo Song, Yuan Gao, Yu-ming Xu, Yu-sheng Li
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Cerebral small vessel disease Cerebral amyloid angiopathy Hypertensive arteriopathy Inflammation Neutrophil–lymphocyte ratio Triglyceride–glucose index Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-62280-z
Popis:	Abstract This study investigated the correlation of newly identified inflammatory and insulin resistance indices with cerebral amyloid angiopathy (CAA), and explored their potential to differentiate CAA from hypertensive arteriopathy (HA). We retrospectively analyzed 514 consecutive patients with cerebral small vessel disease (CSVD)-related haemorrhage, comparing the differences in novel inflammatory and insulin resistance indices between patients with CAA and HA. Univariate regression, LASSO and multivariate regression were used to screen variables and construct a classification diagnosis nomogram. Additionally, these biomarkers were explored in patients with mixed haemorrhagic CSVD. Inflammatory indices were higher in CAA patients, whereas insulin resistance indices were higher in HA patients. Further analysis identified neutrophil-to-lymphocyte ratio (NLR, OR 1.17, 95% CI 1.07–1.30, P
Databáze:	Directory of Open Access Journals
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