A direct role of RNA polymerase III and RNA in DNA homologous recombination

Autor: Sijie Liu, Daochun Kong
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Molecular & Cellular Oncology, Vol 8, Iss 4 (2021)
Druh dokumentu: article
ISSN: 2372-3556
23723556
DOI: 10.1080/23723556.2021.1935173
Popis: End resection excises several thousand bases from the 5ʹ-ended strand during DNA double-strand break repair, creating 3ʹ-end single-stranded DNA overhangs. This overhang requires strict protection from DNA2 or other nucleases digestion. A recent finding showed that the 3ʹ-end overhangs are protected by the transient formation of RNA-DNA hybrids, and RNA polymerase III is an essential factor for homologous recombination.
Databáze: Directory of Open Access Journals
Nepřihlášeným uživatelům se plný text nezobrazuje