The spatial transcriptomic landscape of non-small cell lung cancer brain metastasis

Autor: Qi Zhang, Rober Abdo, Cristiana Iosef, Tomonori Kaneko, Matthew Cecchini, Victor K. Han, Shawn Shun-Cheng Li
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-33365-y
Popis: Brain metastases (BrMs) in non-small cell lung cancer (NSCLC) are associated with dismal outcomes, and are possibly sustained by the brain microenvironment. Here, the authors analyse NSCLC BrMs using Digital Spatial Profiling and reveal fibrosis, immune suppression, and cell reprogramming in the BrM microenvironment.
Databáze: Directory of Open Access Journals