| Autor: |
Ashwini R Nargund, Geeta V Patil, C P Raghuram, Eswarachary Venkataswamy |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Indian Journal of Pathology and Microbiology, Vol 55, Iss 4, Pp 574-577 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
0377-4929 |
| DOI: |
10.4103/0377-4929.107828 |
| Popis: |
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. APL is rare in children (approximately 10% of childhood AML) and is characterized by a higher incidence of hyperleukocytosis, an increased incidence of microgranular morphology, the presence of balanced t(15;17)(q22;q11.2-12) translocation, and more frequent occurrence of the PML-RARα isoforms bcr 2 and bcr 3 compared to adults. The cytomorphology of microgranular variant blasts is obviously different from AML M3 blasts; these cells have a nongranular or hypogranular cytoplasm or contain fine dust-like cytoplasmic azurophil granules that may not be apparent by light microscopy. This case report emphasizes the importance of a high index of suspicion for the diagnosis of APL, the hypogranular variant in particular. They are responsive to differentiation therapy with all trans-retinoic acid and complete remission in seen in >80% cases. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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