Development and validation of RP-LC and uv spectrophotometric methods to assay bromopride in oral and injectable solutions
| Autor: | Márcia Camponogara Fontana, Felipe Kellermann Hurtado, Micheli Wrasse, Aline Augusti Boligon, Tarcieli Pozzebon Venturini, Clarice Madalena Bueno Rolim, Ruy Carlos Ruver Beck |
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| Jazyk: | English<br />Spanish; Castilian<br />Portuguese |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Química Nova, Vol 33, Iss 1, Pp 208-211 (2010) |
| Druh dokumentu: | article |
| ISSN: | 0100-4042 1678-7064 |
| DOI: | 10.1590/S0100-40422010000100035 |
| Popis: | A reversed-phase liquid chromatographic (LC) and ultraviolet (UV) spectrophotometric methods were developed and validated for the assay of bromopride in oral and injectable solutions. The methods were validated according to ICH guideline. Both methods were linear in the range between 5-25 μg mL-1 (y = 41837x - 5103.4, r = 0.9996 and y = 0.0284x - 0.0351, r = 1, respectively). The statistical analysis showed no significant difference between the results obtained by the two methods. The proposed methods were found to be simple, rapid, precise, accurate, and sensitive. The LC and UV methods can be used in the routine quantitative analysis of bromopride in oral and injectable solutions. |
| Databáze: | Directory of Open Access Journals |
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