| Autor: |
Kachi R. Kishore Kumar Reddy, Giovanna B. Longato, João E. de Carvalho, Ana L. T. G. Ruiz, Luiz F. Silva, Jr. |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Molecules, Vol 17, Iss 8, Pp 9621-9630 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1420-3049 |
| DOI: |
10.3390/molecules17089621 |
| Popis: |
An efficient and concise synthesis of nine populene D analogues was performed using an iodine-catalyzed Prins cyclization as the key transformation. The antiproliferative activity of these new pyrans against several cancer cell lines was then investigated. Among them, an isochromene with moderate activity (mean logGI50 = 0.91) was found. Additionally, compounds with selectivity toward the tumor cell lines NCI-ADR/RES, OVCAR-3, and HT29 were discovered. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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