A standardized method for collection of human placenta samples in the age of functional magnetic resonance imaging
| Autor: | Victoria HJ Roberts, Jessica E Gaffney, Katherine S Lewandowski, Matthias C Schabel, Terry K Morgan, Antonio E Frias |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | BioTechniques, Vol 67, Iss 2, Pp 45-49 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1940-9818 0736-6205 |
| DOI: | 10.2144/btn-2019-0029 |
| Popis: | Current methods for placental tissue collection assess a delivered organ without direct functional correlates; therefore, the four-quadrant biopsy protocol utilized by many researchers may provide reasonable representation of tissue across a large organ, and offer a snapshot for molecular analysis of the placenta. However, the recent impetus to understand the placenta in real time, and the use of functional imaging to comprehend placental biology, warrants a different sampling approach. Here we present a method to standardize placental tissue collection in a format designed to facilitate correlation of in vivo function with ex vivo assessments. Additionally, we draw comparisons to the quadrant biopsy regimen, and highlight a pathological case of placental infarction detected by in utero imaging. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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