Cancer-associated fibroblast-related prognostic signature predicts prognosis and immunotherapy response in pancreatic adenocarcinoma based on single-cell and bulk RNA-sequencing

Autor:	Yajun Chen, Qican Deng, Hui Chen, Jianguo Yang, Zhenzhou Chen, Juncai Li, Zhongxue Fu
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Medicine Science
Zdroj:	Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-023-43495-y
Popis:	Abstract Cancer-associated fibroblasts (CAFs) influence many aspects of pancreatic adenocarcinoma (PAAD) carcinogenesis, including tumor cell proliferation, angiogenesis, invasion, and metastasis. A six-gene prognostic signature was constructed for PAAD based on the 189 CAF marker genes identified in single-cell RNA-sequencing data. Multivariate analyses showed that the risk score was independently prognostic for survival in the TCGA (P
Databáze:	Directory of Open Access Journals
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