A case of aspirin-resistance probably related to glycemic excursion
| Autor: | Ilaria Fava, Raffaele Marfella, Giuseppe Paolisso, Maria Rosaria Rizzo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Clinical Management Issues, Vol 4, Iss 4, Pp 131-135 (2010) |
| Druh dokumentu: | article |
| ISSN: | 1973-4832 2283-3137 |
| DOI: | 10.7175/cmi.v4i4.520 |
| Popis: | Diabetes is characterised by development of specific microvascular complications and by a high incidence of accelerated atherosclerosis. Several Authors demonstrated that post-prandial hyperglycaemia is certainly an independent risk factor of vascular complications in type 2 diabetes. The endothelial dysfunction, the oxidative stress, the post-prandial hyperglycaemia and the haemostatic and thrombotic parameters alterations are the principal causes for the cardiovascular risk increase in diabetic patient. For this reason many studies on anti-platelet therapy have been made in order to reduce thrombotic complication of diabetes mellitus. However, data suggest that the clinical efficacy of low-dose aspirin in patients with diabetes is substantially lower than in individuals without diabetes. Indeed, several evidences support the hypothesis that diabetes might represent a case of “aspirin resistance”. |
| Databáze: | Directory of Open Access Journals |
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