Dietary and lifestyle risk factors associated with age-related macular degeneration: A hospital based study
| Autor: | Bhatiwada Nidhi, Bangera Sheshappa Mamatha, Chamrajnagar Anantharajiah Padmaprabhu, Prabhu Pallavi, Baskaran Vallikannan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Amblyopia
nasolacrimal duct obstruction probing Duane syndrome esotropia strabismus Bevacizumab mitochondrial function microvascular endothelial cells neurosensory retinal cells retinal pigment epithelial cells tissue culture Clinical donor tissue grading death to enucleation time death to preservation time eye bank specular microscopy optimizing donor tissue utilization DCR endodiathermy bipolar probe recanalize Age-related macular degeneration carotenoids cross-sectional studies lutein Ophthalmology RE1-994 |
| Zdroj: | Indian Journal of Ophthalmology, Vol 61, Iss 12, Pp 722-727 (2013) |
| Druh dokumentu: | article |
| ISSN: | 0301-4738 1998-3689 31702848 |
| DOI: | 10.4103/0301-4738.120218 |
| Popis: | Aim : To establish the frequency, associations and risk factors for age-related macular degeneration (AMD) in hospital population of South India. Materials and Methods : In this cross-sectional hospital based study, 3549 subjects (2090 men and 1459 women) above 45 years of age were screened randomly for AMD. Participants underwent ocular evaluation and were interviewed for lifestyle variables and dietary intake of carotenoids by structured food frequency questionnaire. AMD was defined according to the international classifications and grading system. Results : Either form of AMD was detected in 77 (2.2%) participants. Of which, early and late AMD was present in 63 (1.8%) and 14 (0.4%) subjects, respectively. Binary logistic analysis showed that the incidence of AMD was significantly higher with increasing age (Odds ratio [OR] 1.17; 95% CI 1.13-1.22) and diabetes (OR 3.97; 95% CI 2.11-7.46). However, AMD was significant among heavy cigarette smokers (OR 5.58; 95% CI 0.88-7.51) and alcoholics (OR 4.85; 95% CI 2.45-12.22). Dietary lutein/zeaxanthin (L/Z) and β-carotene intake were associated (P < 0.001) with the reduction in risk for AMD, with an OR of 0.38 and 0.65, respectively. Conclusions : Higher dietary intake of carotenoids, especially L/Z, was associated with lower risk for AMD. Risk of AMD is higher with increasing age and was prevalent among subjects with diabetes. Cessation of smoking and alcohol may reduce the risk of AMD in this population. |
| Databáze: | Directory of Open Access Journals |
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