Three New Benzophenone Derivatives from Selaginella tamariscina

Autor:	Jiayin Long, Qingqing Mao, Yujie Peng, Lei Liu, Yin Hong, Honglin Xiang, Ming Ma, Hui Zou, Junwei Kuang
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Selaginella Selaginella tamariscina benzophenone selagibenzophenones D-F cytotoxicity NO inhibitory effects Organic chemistry QD241-441
Zdroj:	Molecules, Vol 28, Iss 12, p 4582 (2023)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules28124582
Popis:	Six compounds including three new benzophenones, selagibenzophenones D-F (1–3), two known selaginellins (4–5) and one known flavonoid (6), were isolated from Selaginella tamariscina. The structures of new compounds were established by 1D-, 2D-NMR and HR-ESI-MS spectral analyses. Compound 1 represents the second example of diarylbenzophenone from natural sources. Compound 2 possesses an unusual biphenyl-bisbenzophenone structure. Their cytotoxicity against human hepatocellular carcinoma HepG2 and SMCC-7721 cells and inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 cells were evaluated. Compound 2 showed moderate inhibitory activity against HepG2 and SMCC-7721 cells, and compounds 4 and 5 showed moderate inhibitory activity to HepG2 cells. Compounds 2 and 5 also exhibited inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production.
Databáze:	Directory of Open Access Journals
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