| Autor: |
Marit F. van den Berg, Hans S. Kooistra, Guy C. M. Grinwis, Stefano Nicoli, Stefania Golinelli, Lisa Stammeleer, Monique E. van Wolferen, Elpetra P. M. Timmermans-Sprang, Maurice M. J. M. Zandvliet, Frank G. van Steenbeek, Sara Galac |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Frontiers in Veterinary Science, Vol 10 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2297-1769 |
| DOI: |
10.3389/fvets.2023.1155804 |
| Popis: |
Pheochromocytomas and paragangliomas (PPGLs) are neuroendocrine tumors arising from the chromaffin cells in the adrenal medulla and extra-adrenal paraganglia, respectively. Local invasion, concurrent disorders, and metastases prevent surgical removal, which is the most effective treatment to date. Given the current lack of effective medical treatment, there is a need for novel therapeutic strategies. To identify druggable pathways driving PPGL development, we performed RNA sequencing on PPGLs (n = 19) and normal adrenal medullas (NAMs; n = 10) of dogs. Principal component analysis (PCA) revealed that PPGLs clearly clustered apart from NAMs. In total, 4,218 genes were differentially expressed between PPGLs and NAMs. Of these, 232 had a log2 fold change of >3 or |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
