| Autor: |
Masahito Hitosugi, Munehiro Niwa, Tomoyoshi Takahashi, Akira Kurosu, Hirohisa Nihei, Toshiaki Nagai, Shogo Tokudome |
| Jazyk: |
angličtina |
| Rok vydání: |
2003 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacological Sciences, Vol 91, Iss 4, Pp 334-336 (2003) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1254/S1347-8613(19)32717-3 |
| Popis: |
We examined the effects on whole blood viscosity and coagulation time of various dosages of the synthetic low-molecular protease inhibitors gabexate mesilate and nafamostat mesilate with an oscillation-type viscometer. When either agent was added, blood viscosity decreased dose-dependently along a sigmoid-like curve. Furthermore, coagulation time was shorter with gabexate mesilate than with nafamostat mesilate owing to the differences of half-life in human blood. Thrombin generation, which results from the activation of coagulation factors, is inhibited by synthetic protease inhibitors and subsequently decreases blood viscosity dose-dependently. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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