Serum Progesterone Levels with The Use of Four Different Types of Vaginal Progesterone in Frozen-Thawed Embryo Transfer Cycles and Related Pregnancy Outcomes
| Autor: | Reiko Shiba, Masayuki Kinutani, Shinichiro Okano, Maki Ikeda, Emi Fukunaga, Yoshihisa Harada, Reo Kawano, Yuko Kikkawa |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | International Journal of Fertility and Sterility, Vol 15, Iss 1, Pp 34-39 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2008-076X 2008-0778 |
| DOI: | 10.22074/ijfs.2021.6235 |
| Popis: | Background: Luteal phase support (LPS) is essential for hormone replacement therapy (HRT) for frozen-thawedembryo transfer (FET). However, the optimal dose and serum progesterone (P4) levels required for pregnancy arecontroversial. We attempted to determine the association between pregnancy outcomes and serum P4 levels administeredvia vaginal suppository for HRT-FET cycles on embryo transfer day.Materials and Methods: This was a secondary analysis of the dataset from the EXCULL trial, which prospectivelyinvestigated pregnancy outcomes of four different P4 vaginal suppositories (Lutinus, Utrogestan, Luteum, andCrinone) for HRT-FET. It was conducted at a private fertility clinic between December 2016 to December 2017.During this trial, 235 cycles were divided into four groups based on serum P4 values (quartile [Q] 1 group: 13.7 ng/mL). We investigated clinicalpregnancy rate (CPR), positive fetal heart rate (FHR), live birth rate (LBR), and miscarriage rate (MR) for eachgroup. A logistic regression analysis was performed using age, body mass index (BMI), and transferred embryosas covariates.Results: Serum P4 values (ng/mL) of each drug were as follows: Lutinus, 13.3 ± 4.9; Utrogestan, 9.3 ± 3.3; Luteum,13.6 ± 4.2; and Crinone, 8.7 ± 3.2 (mean ± standard deviation, p |
| Databáze: | Directory of Open Access Journals |
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