Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity

Autor:	Ayland C. Letsinger, James M. Ward, Rick D. Fannin, Debabrata Mahapatra, Matthew F. Bridge, Robert C. Sills, Kevin E. Gerrish, Jerrel L. Yakel
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Medicine Science
Zdroj:	Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-023-29118-6
Popis:	Abstract Individuals infected by SARS-CoV-2 are at risk of developing neurological-related post-acute disorders. Disputed epidemiological data indicated nicotine may reduce the severity of infection. Here we find exposure to nicotine in drinking water does not alter the moribundity of hACE2 mice. However, pre-exposure to nicotine decreased the likelihood of SARS-CoV-2 RNA expression and pathology in the brain. These results suggest mechanisms involving targets of nicotine could be leveraged to prevent the neurovirulence of SARS-CoV-2.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/a94472cf3e3e46a2bce2f15c2e749ed5 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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