| Autor: |
Romain Attal, Ashraf Bakkar, Frédéric Bouillaud, Anne Devin, Marc Henry, Maxime Pontié, Miroslav Radman, Laurent Schwartz |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Advances in Redox Research, Vol 10, Iss , Pp 100087- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2667-1379 |
| DOI: |
10.1016/j.arres.2023.100087 |
| Popis: |
Cancer cells are very diverse but mostly share a common metabolic property: they are strongly glycolytic even though oxygen is available. Herein, the metabolic abnormalities of cancer cells are interpreted as modifications of the electric currents in redox reactions. A lower current in the electron transport chain, an increase of the concentration of reduced cofactors and a partial reversal of the tricarboxylic acid cycle are physical characteristics of several forms of cancer. The existence of electric short-circuits between oxidative branches and reductive branches of the metabolic network argue in favor of an electronic approach of cancer in the nanoscopic scale. These changes of electron flows induce a pseudo-hypoxia and the Warburg effect through succinate production and divert electrons from oxygen to biosynthetic pathways. This new look at cancer may have potential therapeutic applications. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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