| Autor: |
Quranayati Quranayati, Nurdin Saidi, Nurliana Nurliana, Rinaldi Idroes, Naufal Gusti, Rosnani Nasution |
| Jazyk: |
English<br />Spanish; Castilian |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal of Pharmacy & Pharmacognosy Research, Vol 11, Iss 2, Pp 308-314 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
0719-4250 |
| DOI: |
10.56499/jppres23.1595_11.2.308 |
| Popis: |
Context: Phyllanthus emblica stem barks are rich in antioxidants, but its utilization for antidiabetic and diabetic complications remains understudied. Aims: To evaluate the efficacy of extracts from P. emblica stem barks in improving diabetic nephropathy and hyperlipidemia in vivo. Methods: P. emblica stem bark powder was dried and macerated using n-hexane, ethyl acetate, and methanol simultaneously. The diabetic condition was induced by streptozotocin (STZ) in male Wistar rats. Treatment interventions included the oral administration of metformin (60 mg/kg body weight) or P. emblica stem bark extracts (200 mg/kg) once a day, where the fasting blood glucose (FBG) and total cholesterol levels were measured before and after the treatment. Results: Rats receiving the ethyl acetate extract exhibited a significantly lower FBG than the control (113.7 ± 15.04 versus 195 ± 19.97 mg/dL; p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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