TRANSFUSION-ASSOCIATED GRAFT-VERSUS-HOST DISEASE
| Autor: | O. V. Goloschapov, I. S. Moiseev, D. E. Pevtsov |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2018 |
| Předmět: |
transfusion-associated graft-versus-host disease
aortocoronary bypass artificial blood circulation hla-typing gamma-irradiation x-ray irradiation of blood components evaluation of allele discrimination of high-polymorphic markers Medical emergencies. Critical care. Intensive care. First aid RC86-88.9 |
| Zdroj: | Вестник анестезиологии и реаниматологии, Vol 13, Iss 5, Pp 58-65 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2078-5658 2541-8653 |
| DOI: | 10.21292/2078-5658-2016-13-5-58-65 |
| Popis: | Transfusion-associated graft-versus-host disease (TA-GvHD) is a very rare but potentially lethal complication occurring after blood components transfusion. Goal of the article: to analyze the literature describing this complication. TA-GvHD can develop due to several factors: quantity and viability of lymphocytes, contained in the transfused blood component, responsiveness of the patient's immune system to replantation of donor lymphocytes and degree of immunological HLA-homology between the donor and the recipient. History and epidemiology of this fatal syndrome, its pathogenesis, clinical manifestations, diagnostics and therapy have been reviewed. It has been shown that the main prevention techniques include abstaining from blood components transfusion collected from close relatives and using special irradiation modes, suppressing proliferation of the donor's lymphocytes. Conclusion: Doctors performing blood components transfusion should note that post-transfusion reaction development in the variant of graft-versus-host might develop in order to provide timely diagnostics and to start the specific treatment of this complication. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|