Optical Coherence Tomography (OCT) for Time-Resolved Imaging of Alveolar Dynamics in Mechanically Ventilated Rats

Autor: Christian Schnabel, Maria Gaertner, Edmund Koch
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Applied Sciences, Vol 7, Iss 3, p 287 (2017)
Druh dokumentu: article
ISSN: 2076-3417
DOI: 10.3390/app7030287
Popis: Though artificial ventilation is an essential life-saving treatment, the mechanical behavior of lung tissue at the alveolar level is still unknown. Therefore, we need to understand the tissue response during artificial ventilation at this microscale in order to develop new and more protective ventilation methods. Optical coherence tomography (OCT) combined with intravital microscopy (IVM) is a promising tool for visualizing lung tissue dynamics with a high spatial and temporal resolution in uninterruptedly ventilated rats. We present a measurement setup using a custom-made animal ventilator and a gating technique for data acquisition of time-resolved sequences.
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