Longitudinal Association between Stressful Life Events and Suicidal Ideation in Adults with Major Depression Disorder: The Mediating Effects of Insomnia Symptoms

Autor: Ya Chen, Xue Han, Yingchen Jiang, Yunbin Jiang, Xinyu Huang, Wanxin Wang, Lan Guo, Ruirui Xia, Yuhua Liao, Huimin Zhang, Kayla M. Teopiz, Roger S. McIntyre, Beifang Fan, Ciyong Lu
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Behavioral Sciences, Vol 14, Iss 6, p 467 (2024)
Druh dokumentu: article
ISSN: 2076-328X
DOI: 10.3390/bs14060467
Popis: Stressful life events (SLEs) and suicidal ideation (SI) are prevalent in persons with major depression disorder (MDD). Less is known about the underlying role of insomnia symptoms in the association between SLEs and SI. This three-wave prospective cohort study sought to investigate the longitudinal association among SLEs, insomnia symptoms, and SI in persons with MDD. The study population included 511 persons with MDD (mean [SD] age, 28.7 [6.7] years; 67.1% were females). Generalized estimated equations (GEEs) were utilized to explore prospective association among exposure of SLEs, insomnia symptoms, and SI. Additionally, a structural equation model (SEM) was employed to estimate the longitudinal mediating effect of insomnia symptoms in the relationship between SLEs and SI. Our study demonstrated that cumulative SLEs were determined to be longitudinally associated with SI in persons with MDD. We further observed that the association between SLEs and SI was significantly mediated by insomnia symptoms. Clinicians assessing persons with MDD, especially those with the history of SLE, could carefully evaluate and promptly treat insomnia symptoms as part of personalized assessment of their depressive illness, thereby achieving early prevention and intervention for suicidal behaviors in persons with MDD.
Databáze: Directory of Open Access Journals
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