TUMOR NECROSIS AND TRANSFORMING GROWTH FACTORS LEVEL IN SUB-CLINICAL STAGE OF CHRONIC HEPATITIS C
| Autor: | T. V. Antonova, N. L. Shironina, N. A. Gavrisheva, T. P. Ses |
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| Jazyk: | ruština |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Медицинская иммунология, Vol 9, Iss 4-5, Pp 499-504 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1563-0625 2313-741X |
| DOI: | 10.15789/1563-0625-2007-4-5-499-504 |
| Popis: | Abstract. Participation of pro- and anti-inflammatory cytokines in pathogenesis of inflammation and fibrosis served as a basis for studying TNFα and TGFβ levels in blood serum from the patients with chronic hepatitis C (CHC), as compared with modes and degree of patho-morphological changes in liver biopsies. We have detected a sufficient increase in serum TGFβ levels from patients in sub-clinical stage of CHC, independent on activity of the inflammatory process and expression of fibrosis, with a trend for its higher levels in cases of clinical decompensation at cirrhotic stage of the disease. Ambiguous changes of TNFα indexes in CHC patients with a tendency of higher levels in cases of higher histological activity and fibrosis of liver tissue allow us to consider a possible correlation with varying degree of compensatory and adaptive reactions. |
| Databáze: | Directory of Open Access Journals |
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