Comprehensive analysis identifies as a critical prognostic prediction gene in breast cancer
| Autor: | Ting Hu, Xu Wang, Yun Xia, Lu Wu, Yuxi Ma, Rui Zhou, Yanxia Zhao, Yanjie Yin, Xiuyuan |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Chinese Medical Journal, Vol 135, Iss 18, Pp 2218-2231 (2022) |
| Druh dokumentu: | article |
| ISSN: | 0366-6999 2542-5641 00000000 |
| DOI: | 10.1097/CM9.0000000000002025 |
| Popis: | Abstract. Background:. Aurora kinases (AURKs) family plays a vital role not only in cell division but also in tumorigenesis. However, there are still rare systematic analyses of the diverse expression patterns and prognostic value of the AURKs family in breast cancer (BC). Systematic bioinformatics analysis was conducted to explore the biological role, prognostic value, and immunologic function of AURKs family in BC. Methods:. The expression, prognostic value, and clinical functions of AURKs family in BC were evaluated with several bioinformatics web portals: ONCOMINE Gene Expression Profiling Interactive Analysis, Kaplan–Meier plotter, cBioPortal, Metascape, GeneMANIA, and LinkedOmics; and the result was verified using human tissues. Results:. The expression of AURKA and AURKB were upregulated in BC in subgroup analyses based on tumor stage (all P |
| Databáze: | Directory of Open Access Journals |
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