| Autor: |
Ali Cetin, Tijen Kaya, Nihal Demirkoprulu, Baris Karadas, Bulent Duran, Meral Cetin |
| Jazyk: |
angličtina |
| Rok vydání: |
2004 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacological Sciences, Vol 94, Iss 1, Pp 19-24 (2004) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1254/jphs.94.19 |
| Popis: |
The aim of this study was to investigate the effect of YC-1 (3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole) on spontaneous contractions and levels of cyclic GMP (cGMP) of myometrial strips isolated from pregnant rats. It is a nitric oxide-independent soluble guanylate cyclase activator. Myometrial strips were obtained from eight pregnant Wistar albino rats and were mounted in organ baths for the recording of isometric tensions. We evaluated the effect of increasing concentrations of YC-1 on spontaneous myometrial contractions and on contractions of myometrial smooth muscle pretreated with methylene blue (10-5M), tetraethylammonium chloride (TEA) (3 × 10-4M), and glibenclamide (10-6M). YC-1 (10-9–3 × 10-5M) concentration-dependently decreased the amplitude and frequency of spontaneous contractions of myometrial strips. The inhibition of the amplitude and frequency of spontaneous contractions by YC-1 were antagonized with methylene blue (10-5M) and TEA (3 × 10-4M), but they were not changed by glibenclamide (10-6M); however, the antagonistic effect of methylene blue was significantly more than that of TEA (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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