| Autor: |
Maxime Samson, Hélène Greigert, Marion Ciudad, Claire Gerard, Thibault Ghesquière, Malika Trad, Marc Corbera‐Bellalta, Coraline Genet, Sethi Ouandji, Claudie Cladière, Marine Thebault, Kim Heang Ly, Eric Liozon, François Maurier, Boris Bienvenu, Benjamin Terrier, Loïc Guillevin, Pierre Charles, Valérie Quipourt, Hervé Devilliers, Pierre‐Henry Gabrielle, Catherine Creuzot‐Garcher, Georges Tarris, Laurent Martin, Philippe Saas, Sylvain Audia, Maria Cinta Cid, Bernard Bonnotte |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Clinical & Translational Immunology, Vol 10, Iss 9, Pp n/a-n/a (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2050-0068 |
| DOI: |
10.1002/cti2.1332 |
| Popis: |
Abstract Objectives To study the percentage, suppressive function and plasticity of Treg in giant cell arteritis (GCA), and the effects of glucocorticoids and tocilizumab. Methods Blood samples were obtained from 40 controls and 43 GCA patients at baseline and after treatment with glucocorticoids + IV tocilizumab (n = 20) or glucocorticoids (n = 23). Treg percentage and phenotype were assessed by flow cytometry. Suppressive function of Treg was assessed by measuring their ability to inhibit effector T‐cell (Teff) proliferation and polarisation into Th1 and Th17 cells. Results Treg (CD4+CD25highFoxP3+) frequency in total CD4+ T cells was decreased in active GCA patients when compared to controls (2.5% vs. 4.7%, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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