Evaluation of urinary enzymes in newborns treated with gentamicin
| Autor: | Ali Mohammadi Karakani, Solmaz Asgharzadeh Haghighi, Mahmoud Ghazi-Khansari, Afsaneh Seyed-Ebrahimi, Sharareh Zeighami-Mohammadi |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Iranian Journal of Basic Medical Sciences, Vol 17, Iss 5, Pp 391-395 (2014) |
| Druh dokumentu: | article |
| ISSN: | 2008-3866 2008-3874 |
| Popis: | Objective(s): In recent years, there has been an increasing amount of study on early diagnosis of kidney injury through sensitive and specific biomarkers. We examined the practical applicability of the urinary levels of NAG (N-acetyl-β-D-glucosaminidase), AP (alkaline phosphatase), and LDH (lactate dehydrogenase) as renal dysfunction screening biomarkers in full and pre-term newborns treated with gentamicin. Materials and Methods: Fourteen pre-term and fifteen full-term newborns who received gentamicin for suspected infections were enrolled. Serum and urine specimens were obtained before the zero days and after gentamicin infusion on the 1st, 3rd, and 5th days of treatment. Results: In full-term newborns a significant increase in urinary NAG, LDH, AP after 5 days of gentamicin administration compared with control group was noted (P |
| Databáze: | Directory of Open Access Journals |
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