Clinico-radio-pathological Features and Biological Behavior of Breast Cancer in Young Indian Women: A Prospective Study

Autor: Rashmi Sudhir, Kamala Sannapareddy, Alekya Potlapalli, Vidhatri Penmetsa
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Indian Journal of Radiology and Imaging, Vol 31, Iss 02, Pp 323-332 (2021)
Druh dokumentu: article
ISSN: 0971-3026
1998-3808
DOI: 10.1055/s-0041-1734342
Popis: Aims The aim of the study is to evaluate the characteristic imaging features of breast cancer on mammogram, ultrasound, and magnetic resonance imaging (MRI) in women less than 40 years of age and to assess the degree of correlation between clinico-radio-pathological features and biological behavior. Methods and Materials A prospective observational study on consecutive women under 40 years of age evaluated with ultrasound of breast, digital mammogram, or contrast-enhanced breast MRI, diagnosed with breast cancer on histopathology and molecular analysis done at our center between January and December 2019 were included. Patient demographics, clinical presentation, family history, BRCA mutation status, imaging, pathological findings, and molecular status were determined. Results Out of 2,470 women diagnosed with breast cancer, 354 (14.3%) were less than 40 years of age who were included in this study. Mammography showed positive findings in 85%, ultrasonography in 94.3%, and MRI in 96.4% of women. Majority of the women (69.6%) presented in the late stage (Stage III and IV) with high-grade carcinoma in 39.5% and triple-negative breast cancer (TNBC) in 45.7%. Tumors with human epidermal growth factor-2neu expression were associated with the presence of microcalcifications (p-value = 0.006), and TNBC with circumscribed margins or BI-RADS 3/4a category on imaging (p-value = 0.007) and high-grade invasive carcinoma compared with others (p-value
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