| Autor: |
Di Wu, Song Wang, Chao Hai, Linfeng Wang, Dongchao Pei, Chunling Bai, Guanghua Su, Xuefei Liu, Yuefang Zhao, Zhonghua Liu, Lei Yang, Guangpeng Li |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Metabolites, Vol 13, Iss 7, p 836 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2218-1989 |
| DOI: |
10.3390/metabo13070836 |
| Popis: |
Myostatin (MSTN) is a negative regulator of skeletal muscle genesis during development. MSTN mutation leads to increased lean meat production and reduced fat deposition in livestock. However, the mechanism by which MSTN promotes myogenesis by regulating metabolism is not clear. In this study, we compared the metabolomics of the livers of wild-type (WT) and MSTN mutation cattle (MT), and found changes in the content and proportion of fatty acids and bile acids in MT cattle. The differential metabolites were enriched in sterol synthesis and primary bile acid synthesis. We further analyzed the expression of genes involved in the regulation of lipid and bile acid metabolism, and found that the loss of MSTN may alter lipid synthesis and bile acid metabolism. This study provides new basic data for MSTN mutations in beef cattle breeding. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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