Structural Diversity and Biological Activities of Diterpenoids Derived from Euphorbia fischeriana Steud

Autor:	Baiyu Jian, Hao Zhang, Jicheng Liu
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	diterpenoids Euphorbia fischeriana Steud bioactivity Organic chemistry QD241-441
Zdroj:	Molecules, Vol 23, Iss 4, p 935 (2018)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules23040935
Popis:	Diterpenoids are the focus of natural product drug discovery because of their great structural diversity and pronounced biological activities. Euphorbia fischeriana Steud is a Chinese traditional medicinal herb for curing edema, ascites, and cancer. This plant contains rich diterpenoids. Based on the carbon skeleton and substituents, it can be classified into thirteen subtypes: ent-abietane, daphnane, tigliane, ingenane, ent-atisane, ent-rosane, ent-kaurene, ent-kaurane, secotigliane, lathyrane, ent-pimarene, isopimarene and dimeric. In this paper, we reviewed the chemical structures and biological activities of 90 diterpenoids isolated from this medicinal herb. We hope that this work can serve as a reference for further research of these diterpenoids and lay the foundation for drug discovery.
Databáze:	Directory of Open Access Journals
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