Phencyclidine: A rare cause of saccadic intrusions

Autor: M N Shameer Nijam, Narmathey Thambirajah, Dhanushka Vithanawasam, Kumarangie Vithanage, Damith S Liyanage, I Kishara Gooneratne, Sunethra Senanayake
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Annals of Indian Academy of Neurology, Vol 22, Iss 4, Pp 503-505 (2019)
Druh dokumentu: article
ISSN: 0972-2327
1998-3549
DOI: 10.4103/aian.AIAN_174_18
Popis: Saccadic intrusions such as opsoclonus and ocular flutter are often due to a paraneoplastic or a parainfectious condition. Toxins/drugs may rarely cause them. Herein, we report a rare case of ocular flutter/opsoclonus due to phencyclidine (PCP) toxicity. Our patient is a 21-year-old male who presented with a 3-day history of headache, generalized ill health, and aggressive behavior. He was admitted with reduced level of consciousness following generalized seizures. He had features of sympathetic overactivity with ocular flutter and opsoclonus. Urine toxicology was positive for PCP. Despite supportive care, he succumbed to complications of rhabdomyolysis. Several drugs including cocaine, phenytoin, lithium, and amitriptyline are known to cause ocular flutter/opsoclonus rarely. It is poorly described with PCP. This case highlights PCP as a rare cause of toxin-induced saccadic intrusions and attempts to postulate its pathogenesis. Moreover, our report is the first case of PCP intoxication in Sri Lanka and one of the few documented reports in the South Asian region. Therefore, it represents a significant worrisome alarm about the spread of this substance in this region.
Databáze: Directory of Open Access Journals
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