Estimation of glomerular filtration rate from serum cystatin C and creatinine in patients with thyroid dysfunction
| Autor: | Čabarkapa Velibor, Mijović Romana, Stošić Zoran, Ćurić Nikola, žeravica Radmila, Ilinčić Branislava |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Journal of Medical Biochemistry, Vol 31, Iss 2, Pp 88-93 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1452-8258 1452-8266 |
| Popis: | Given that thyroid function influences serum cystatin C and creatinine levels, the question arises as to whether it is possible to accurately estimate glomerular filtration rate (GFR) in patients with thyroid dysfunction. The objective of the study was to determine serum cystatin C and creatinine levels and estimate GFR in patients with thyroid dysfunction. The study included 32 cases with newly diagnosed hyperthyroidism and 27 cases with newly diagnosed hypothyroidism, as well as 20 healthy controls matched for sex and age with the cases. Serum concentrations of thyroid stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4), creatinine and cystatin C were measured in all study subjects. GFR was estimated using the Modification of Diet in Renal Disease (MDRD), the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and cystatin C-based equations. Serum cystatin C levels were significantly higher in hyperthyroid subjects compared to controls (1.32±0.31 vs. 0.89±0.15; p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|