Molecular epidemiological analysis of HIV-1 variants circulating in Russia in 1987—2015

Autor: I A Lapovok, A E Lopatukhin, D E Kireev, E V Kazennova, A V Lebedev, M R Bobkova, A N Kolomeets, G I Turbina, G A Shipulin, N N Ladnaya, V V Pokrovsky
Jazyk: ruština
Rok vydání: 2017
Předmět:
Zdroj: Терапевтический архив, Vol 89, Iss 11, Pp 44-49 (2017)
Druh dokumentu: article
ISSN: 0040-3660
2309-5342
DOI: 10.17116/terarkh2017891144-49
Popis: Aim. To simultaneously analyze HIV-1 samples from all Russian regions to characterize the epidemiology of HIV infection in the country as a whole. Subjects and methods. The most extensive study was conducted to examine nucleotide sequences of the pol gene of HIV-1 samples isolated from HIV-positive persons in different regions of Russia, with the diagnosis date being fixed during 1987—2015. The nucleotide sequences of the HIV-1 genome were analyzed using computer programs and on-line applications to identify a virus subtype and new recombinant forms. Results. The nucleotide sequences of the pol gene were analyzed in 1697 HIV-1 samples and the findings were that the genetic variant subtype A1 (IDU-A) was dominant throughout the entire territory of Russia (in more than 80% of all infection cases). Other virus variants circulating in Russia were analyzed; the phenomenon of the higher distribution of the recombinant form CRF63/02A in Siberia, which had been previously described in the literature, was also confirmed. Four new recombinant forms generated by the virus subtype A1 (IDU-A) and B and two AG recombinant forms were found. There was a larger genetic distance between the viruses of IDU-A variant circulating among the injecting drug users and those infected through heterosexual contact, as well as a change in the viruses of subtype G that caused the outbreak in the south of the country over time in 1988—1989. Conclusion. The findings demonstrate continuous HIV-1 genetic variability and recombination over time in Russia, as well as increased genetic diversity with higher HIV infection rates in the population.
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