The dilemma: scleroderma renal crisis vs lupus nephritis in a patient with mixed connective tissue disorder

Autor: Nicola Jackson, Shion Betty, James Appiah-Pippim, Yolin Bueno, Sana Makhdumi
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 6, Pp 852-855 (2021)
Druh dokumentu: article
ISSN: 2000-9666
20009666
DOI: 10.1080/20009666.2021.1983320
Popis: Introduction Mixed connective tissue disorder (MCTD) is a rare connective tissue disorder characterized by features of systemic lupus erythematosus, dermatomyositis, systemic sclerosis, and rheumatoid arthritis. MCTD is associated with an elevated antibody titer to U1 small nuclear ribonucleoprotein. Case description: A 49-year-old man presented to the emergency department for evaluation of worsening shortness of breath with associated for bilateral hand pain and swelling associated with morning stiffness which was initially thought to be related to systemic lupus erythematous (SLE). He was also found to have a positive autoantibody, and he was later diagnosed with MCTD complicated by scleroderma renal crisis. Conclusion MCTD is a rare connective tissue disorder with overlapping features of SLE, dermatomyositis, systemic sclerosis, and rheumatoid arthritis. The diagnosis of MCTD requires a high index of suspicion and careful workup. Immunosuppressive therapy is the mainstay of treatment that improves patient outcomes.
Databáze: Directory of Open Access Journals
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