Live donor hepatectomy for liver transplantation in Egypt: Lessons learned

Autor: Emad Kamel, Mohamed Abdullah, Ashraf Hassanin, Nirmeen Fayed, Fatma Ahmed, Hossam Soliman, Osama Hegazi, Yasmine Abd El Salam, Magdy Khalil, Khaled Yassen, Ibrahim Marwan, Koichi Tanaka, Khaled AboElla, Tarek Ibrahim
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Saudi Journal of Anaesthesia, Vol 6, Iss 3, Pp 234-241 (2012)
Druh dokumentu: article
ISSN: 1658-354X
DOI: 10.4103/1658-354X.101214
Popis: Purpose: To retrospectively review anesthesia and intensive care management of 145 consented volunteers subjected to right lobe or left hepatectomy between 2003 and 2011. Methods: After local ethics committee approval, anesthetic and intensive care charts, blood transfusion requirements, laboratory data, complications and outcome of donors were analyzed. Results: One hundred and forty-three volunteers successfully tolerated the surgery with no blood transfusion requirements, but with a morbidity rate of (50.1%). The most frequent complication was infection (21.1%) (intraabdominal collections), followed by biliary leak (18.2%). Two donors had major complications: one had portal vein thrombosis (PVT) treated with vascular stent. This patient recovered fully. The other donor had serious intraoperative bleeding and developed postoperative PVT and liver and renal failure. He died after 12 days despite intensive treatment. He was later reported among a series of fatalities from other centers worldwide. Epidural analgesia was delivered safely (n=90) with no epidural hematoma despite significantly elevated prothrombin time (PT) and international normalization ratio (INR) postoperatively, reaching the maximum on Day 1 (16.9±2.5 s and 1.4±0.2, P
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