Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype in mice

Autor: T. M. O’Shea, Y. Ao, S. Wang, A. L. Wollenberg, J. H. Kim, R. A. Ramos Espinoza, A. Czechanski, L. G. Reinholdt, T. J. Deming, M. V. Sofroniew
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-33382-x
Popis: Effects of lesion environments on transplanted neural progenitor cells (NPC) are not well characterized. Here, the authors show that NPC transplanted into CNS lesions generate cells that share transcriptional and functional features with host wound repair astroglia in mice.
Databáze: Directory of Open Access Journals