Exploring antibiotic resistance mechanisms in Mycobacterium abscessus for enhanced therapeutic approaches

Autor: Thanh Quang Nguyen, Bo Eun Heo, Seunghyeon Jeon, Anwesha Ash, Heehyun Lee, Cheol Moon, Jichan Jang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Microbiology, Vol 15 (2024)
Druh dokumentu: article
ISSN: 1664-302X
DOI: 10.3389/fmicb.2024.1331508
Popis: Mycobacterium abscessus, a leading cause of severe lung infections in immunocompromised individuals, poses significant challenges for current therapeutic strategies due to resistance mechanisms. Therefore, understanding the intrinsic and acquired antibiotic resistance of M. abscessus is crucial for effective treatment. This review highlights the mechanisms employed by M. abscessus to sustain antibiotic resistance, encompassing not only conventional drugs but also newly discovered drug candidates. This comprehensive analysis aims to identify novel entities capable of overcoming the notorious resistance exhibited by M. abscessus, providing insights for the development of more effective therapeutic interventions.
Databáze: Directory of Open Access Journals