Comparison of Fasting Insulin Level, Homeostatic Model of Insulin Resistance, and Lipid Levels between Patients with Primary Hypertension and Normotensive Subjects

Autor: Rithvik Ramesh, Viswanathan Pandurangan, Sudha Madhavan, Devasena Srinivasan, Emmanuel Bhaskar, Lakshmi Marappa, Aiswarya M. Nair, Vaasanthi Rajendran, Priyadarshini Varadaraj
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Rambam Maimonides Medical Journal, Vol 13, Iss 2, p e0009 (2022)
Druh dokumentu: article
ISSN: 2076-9172
DOI: 10.5041/RMMJ.10468
Popis: Background: Hyperinsulinemia and insulin resistance occurs in obese patients with primary hypertension independent of diabetes and obesity. This study was aimed at assessing serum fasting insulin levels, the homeostatic model assessment for insulin resistance (HOMA-IR), and serum lipid levels in non-obese patients with primary hypertension when compared to normotensive subjects. Methods: This observational study comprised 100 patients over 18 years of age, divided into two groups. The hypertensive group comprised non-obese patients with primary hypertension (n=50); the normotensive group comprised normotensive age- and sex-matched individuals (n=50). Patients with diabetes, impaired fasting glucose, obesity, and other causative factors of insulin resistance were excluded from the study. Serum fasting insulin levels and fasting lipid profiles were measured, and insulin resistance was calculated using HOMA-IR. These data were compared between the two groups. Pearson’s correlation coefficient was used to assess the extent of a linear relationship between HOMA-IR and to evaluate the association between HOMA-IR and systolic and diastolic blood pressures. Results: Mean serum fasting insulin levels (mIU/L), mean HOMA-IR values, and fasting triglyceride levels (mg/dL) were significantly higher in the hypertensive versus normotensive patients (10.32 versus 6.46, P
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