Esophageal Carcinosarcoma: Analysis of Clinical Features and Prognosis of 24 Cases and a Literature Review

Autor: Shusen Chen MD, Yu Shi MD, Zhengjing Lu MD, Mingwei Wang MD, Longfei Cong MD, Baixia Yang MD, Xudong Chen MD, Jing Cai MD, Xi Yang MD, PhD
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Cancer Control, Vol 28 (2021)
Druh dokumentu: article
ISSN: 1073-2748
10732748
DOI: 10.1177/10732748211004886
Popis: Objective: Esophageal carcinosarcoma (ECS) is a rare malignant tumor that accounts for only 0.5%-2.8% of all esophageal malignancies. As most current studies are case reports, the relationship between clinical features and prognosis remains controversial. Methods: We investigated the clinical features and prognosis of 24 patients with ECS in a single center from 2006 to 2018. There were 18 male and 6 female patients aged 52-82 years with a median age of 62.5 years. In addition, we included 9 studies on ECS from PubMed and a literature review. Results: The median follow-up time of the 24 patients was 70.5 (range, 10-156)months. The 3-year and 5-year survival rates were 83.3% and 70.8%, respectively. Among the 24 patients, none of the 10 (41.7%) stage T 1 cancer patients had lymph node metastasis; however, lymph node metastasis was noted in 8 (57.1%) stage T 2-4 cancer patients. The literature review revealed that 211 patients had a 5-year survival rate of 11.8%-68.2%, and 54.5%-95.8% study participants had early stage ECS. Although the information provided in the literature review is limited, it appears to be a characteristic of the early stage of the disease and predicts better prognosis when ECS is diagnosed, which is similar to the result of the current study. Conclusion: Our results indicate that ECS has a favorable prognosis, even among patients with early stage ECS who undergo radical esophagectomy with lymph node dissection. Because of the low incidence of ECS, further studies with more cases need to investigate this rare malignancy.
Databáze: Directory of Open Access Journals
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