The Relationship Between Serum Levels of Total IgE, IL-18, IL-12, IFN-γ and Disease Severity in Children With Atopic Dermatitis
| Autor: | Murat Aral, Ozer Arican, Mustafa Gul, Sezai Sasmaz, Sumeyra Alkis Kocturk, Ummugulsum Kastal, Hasan Cetin Ekerbicer |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Mediators of Inflammation, Vol 2006 (2006) |
| Druh dokumentu: | article |
| ISSN: | 0962-9351 1466-1861 |
| DOI: | 10.1155/MI/2006/73098 |
| Popis: | Studies about the role of cytokines on the immunopathogenesis of atopic dermatitis (AD) are generally based on in vitro observations and this role has not been completely clarified yet. Serum levels of total IgE, IL-18, IL-12, IFN-γ and the relationship between these parameters and disease severity, determined using the SCORAD index, in a group of atopic patients were investigated in this study. Serum levels of total IgE were measured by the nephelometric method and serum levels of IL-18, IL-12/p40 and IFN-γ were measured by ELISA method. Serum levels of total IgE and IL-18 were found significantly higher in study group than in controls (P |
| Databáze: | Directory of Open Access Journals |
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