ASC nanobodies to counteract the consequences of inflammasome activation
| Autor: | Sahil Adriouch, Pablo Pelegrin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | EMBO Molecular Medicine, Vol 14, Iss 6, Pp n/a-n/a (2022) |
| Druh dokumentu: | article |
| ISSN: | 1757-4684 1757-4676 93540582 |
| DOI: | 10.15252/emmm.202216087 |
| Popis: | Inflammasomes are multiprotein complexes that signal by oligomerizing the apoptosis speck‐like protein with caspase recruitment and activator domain (ASC) and are involved in multiple inflammatory, metabolic and degenerative diseases. Pharmacological targeting of specific inflammasomes with small molecules is leading to the development of novel drugs for most common diseases. The targeting of ASC oligomers will result in a pan‐inflammasome treatment. In their study, Bertheloot et al (2022) developed specific anti‐ASC nanobodies and showed their efficacy to disaggregate already formed ASC oligomers and to treat inflammatory diseases in animal models. This approach represents a novel biologic‐based treatment for inflammasomes‐initiated inflammatory diseases. |
| Databáze: | Directory of Open Access Journals |
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