Lower HBV DNA level is associated with more severe liver fibrosis in HBeAg-positive chronic hepatitis B with normal alanine transaminase

Autor:	Jian Wang, Li Zhu, Zhiyi Zhang, Shaoqiu Zhang, Yifan Pan, Yuanyuan Li, Fei Cao, Chao Jiang, Tao Fan, Ye Xiong, Jiacheng Liu, Yuxin Chen, Shengxia Yin, Xin Tong, Chuanwu Zhu, Xingxiang Liu, Jie Li, Chao Wu, Rui Huang
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Chronic hepatitis B Immune-tolerant HBV DNA Liver fibrosis Cirrhosis Infectious and parasitic diseases RC109-216
Zdroj:	Virology Journal, Vol 21, Iss 1, Pp 1-9 (2024)
Druh dokumentu:	article
ISSN:	1743-422X
DOI:	10.1186/s12985-024-02368-0
Popis:	Abstract Background The association of hepatitis B virus (HBV) DNA levels and liver fibrosis in chronic hepatitis B (CHB) patients with immune-tolerant phase remains unclear. We explored the association between liver fibrosis and HBV DNA levels in HBeAg-positive CHB patients with normal alanine transaminase (ALT) with relatively high HBV DNA. Methods Six hundred and twenty-two HBeAg-positive CHB patients with normal ALT were included. Patients were divided into three categories: low (6 log10 IU/mL ≤ HBV DNA
Databáze:	Directory of Open Access Journals
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