| Autor: |
Arzu EROL |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Bezmiâlem Science, Vol 9, Iss 2, Pp 134-139 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2148-2373 |
| DOI: |
10.14235/bas.galenos.2020.4056 |
| Popis: |
Objective:An important criterion that radiopaque poly-3-hydroxy butyrate (PHB) derivatives synthesized and characterized by our study group do not interact with DNA and bovine albumin to be developed as an intravenous contrast agent for radiological imaging.Methods:Interactions of radiopaque PHB derivatives between bovine serum albumin (BSA) and deoxyribonucleic acid (pUC19 DNA and polymerase chain reaction product) were investigated using absorption spectroscopy and agarose gel electrophoresis techniques.Results:Absorption spectroscopy results showed that the radiopaque PHB derivatives did not show any interaction with BSA. Doublestranded annular DNA showed that the interaction between the double-stranded forms of linear DNA did not cause any damage.Conclusion:It was determined that it did not interact with both BSA and various DNA forms. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
