Research Progress of Central and Peripheral Corticotropin-Releasing Hormone in Irritable Bowel Syndrome with Comorbid Dysthymic Disorders

Autor: Yi Feng Liang, Xiao Qi Chen, Meng Ting Zhang, He Yong Tang, Guo Ming Shen
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Gut and Liver, Vol 18, Iss 3, Pp 391-403 (2024)
Druh dokumentu: article
ISSN: 1976-2283
DOI: 10.5009/gnl220346
Popis: Irritable bowel syndrome (IBS) is considered a stress disorder characterized by psychological and gastrointestinal dysfunction. IBS patients not only suffer from intestinal symptoms such as abdominal pain, diarrhea, or constipation but also, experience dysthymic disorders such as anxiety and depression. Studies have found that corticotropin-releasing hormone plays a key role in IBS with comorbid dysthymic disorders. Next, we will summarize the effects of corticotropin-releasing hormone from the central nervous system and periphery on IBS with comorbid dysthymic disorders and relevant treatments based on published literatures in recent years.
Databáze: Directory of Open Access Journals