Bleomycin-induced flagellate hyperpigmentation: Clinical Image

Autor: Shanta Sutradhar, Sumit Kar, Sushil K Varma, Bhusan Madke
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Journal of Mahatma Gandhi Institute of Medical Sciences, Vol 19, Iss 1, Pp 72-73 (2014)
Druh dokumentu: article
ISSN: 0971-9903
DOI: 10.4103/0971-9903.126263
Popis: Flagellate hyperpigmentation is a unique complication of systemic bleomycin sulfate therapy. It has an onset anywhere between 1 day and several months after administration for various indications and these eruptions are usually dose-dependent. The dose of bleomycin required to produce such an effect is usually more than 100 U but it can also occur at lower doses also. Herewith, we describe a case with clinical image of ovarian dysgerminoma that presented with typical linear and streaked pigmentation following a very low dose (30 U) of systemic bleomycin therapy which appeared within 24 h of administration and increased gradually after subsequent doses.
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