Experimental Infection of Horses with West Nile virus
| Autor: | Michel L. Bunning, Richard A. Bowen, C. Bruce Cropp, Kevin G. Sullivan, Brent S. Davis, Nicholas Komar, Marvin S. Godsey, Dale Baker, Danielle L. Hettler, Derek A. Holmes, Brad J. Biggerstaff, Carl J. Mitchell |
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| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: | |
| Zdroj: | Emerging Infectious Diseases, Vol 8, Iss 4, Pp 380-386 (2002) |
| Druh dokumentu: | article |
| ISSN: | 1080-6040 1080-6059 |
| DOI: | 10.3201/eid0804.010239 |
| Popis: | A total of 12 horses of different breeds and ages were infected with West Nile virus (WNV) via the bites of infected Aedes albopictus mosquitoes. Half the horses were infected with a viral isolate from the brain of a horse (BC787), and half were infected with an isolate from crow brain (NY99-6625); both were NY99 isolates. Postinfection, uninfected female Ae. albopictus fed on eight of the infected horses. In the first trial, Nt antibody titers reached >1:320, 1:20, 1:160, and 1:80 for horses 1 to 4, respectively. In the second trial, the seven horses with subclinical infections developed Nt antibody titers >1:10 between days 7 and 11 post infection. The highest viremia level in horses fed upon by the recipient mosquitoes was approximately 460 Vero cell PFU/mL. All mosquitoes that fed upon viremic horses were negative for the virus. Horses infected with the NY99 strain of WNV develop low viremia levels of short duration; therefore, infected horses are unlikely to serve as important amplifying hosts for WNV in nature. |
| Databáze: | Directory of Open Access Journals |
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