| Autor: |
Nadera J Sweiss, Rafah Salloum, Seema Gandhi, Maria-Luisa Alegre, Ray Sawaqed, Maria Badaracco, Kenneth Pursell, David Pitrak, Robert P Baughman, David R Moller, Joe G N Garcia, Timothy B Niewold |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 5, Iss 2, p e9088 (2010) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0009088 |
| Popis: |
Sarcoidosis is a poorly understood chronic inflammatory condition. Infiltration of affected organs by lymphocytes is characteristic of sarcoidosis, however previous reports suggest that circulating lymphocyte counts are low in some patients with the disease. The goal of this study was to evaluate lymphocyte subsets in peripheral blood in a cohort of sarcoidosis patients to determine the prevalence, severity, and clinical features associated with lymphopenia in major lymphocyte subsets.Lymphocyte subsets in 28 sarcoid patients were analyzed using flow cytometry to determine the percentage of CD4, CD8, and CD19 positive cells. Greater than 50% of patients had abnormally low CD4, CD8, or CD19 counts (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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