Heterogeneous trajectories in schizophrenia: insights from neurodevelopment and neuroprogression models
| Autor: | Ramiro Reckziegel, Letícia S. Czepielewski, Mathias Hasse-Sousa, Dayane S. Martins, Maria J. de Britto, Clara de O. Lapa, Alexandre W. Schwartzhaupt, Clarissa S. Gama |
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| Jazyk: | English<br />Portuguese |
| Předmět: | |
| Zdroj: | Brazilian Journal of Psychiatry |
| Druh dokumentu: | article |
| ISSN: | 1809-452X 1516-4446 |
| DOI: | 10.1590/1516-4446-2020-1670 |
| Popis: | The notion that schizophrenia is a neuroprogressive disorder is based on clinical perception of cumulative impairments over time and is supported by neuroimaging and biomarker research. Nevertheless, increasing evidence has indicated that schizophrenia first emerges as a neurodevelopmental disorder that could follow various pathways, some of them neuroprogressive. The objective of this review is to revisit basic research on cognitive processes and neuroimaging findings in a search for candidate keys to the intricate connections between neurodevelopment and neuroprogression in schizophrenia. In the complete panorama, schizophrenia is a neurodevelopmental disorder, possibly associated with an additional burden over the course of the disease through pathologically accelerated aging, and cognitive heterogeneity may explain the different trajectories of each patient. |
| Databáze: | Directory of Open Access Journals |
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