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ObjectiveTo examine the prevalence and drug resistance of bacterial diarrhea-related pathogens in Ningxia Hui Autonomous Region (Ningxia) for providing evidences to the prevention and control of infectious diarrhea. MethodsTotally 3 486 stool samples were collected from diarrhea patients visiting 15 sentinel hospitals in Ningxia from 2018 through 2020. Bacteria strains were isolated and identified with isolation culture methods and drug susceptibility test was performed for isolated predominant strains using broth dilution method. ResultsTotally 287 pathogenic bacterial strains were isolated, including strains of Salmonella, Diarrheogenic Escherichia coli, Yersinia Enterocolitica, Shigella, Klebella pneumoniae, Staphylococcus aureus and Staphylococcus aureus. For the 83 Samonella strains, the resistance to ampicillin was the highest, followed by that to tetracycline, cefazolin and nalidixic acid; the strains were the most sensitive to imipenem, with the susceptibility rate of 100% for the strains isolated in 2019 and 2020, and the strains were also sensitive to azithromycin. For the 146 strains of diarrheogenic Escherichia coli, the rate of resistance to ampicillin was the highest; while the rate of sensitivity to imipenem was the highest, followed by that to cefastadidine, cefacidine, and azithromycin. ConclusionThere were multiple pathogenic bacteria inducing diarrheal diseases in Ningxia between 2018 and 2020, with the Salmonella and diarrheogenic Escherichia coli strains being predominant pathogens which were most resistant to ampicillin and sensitive to imipenem. Surveillance on diarrheal pathogens should be strengthened for developing effective measures on diarrhea disease prevention. |
